• 李闯创课题组完成高难度明星分子Vinigrol的最短全合成 近日,我胁四癫势弊钚峦?;到淌诶畲炒纯翁庾樵诠识ゼ饣诳睹拦Щ嶂尽罚↗ournal of the American Chemical Society,简称JACS)发表论文,报道了明星天然产物Vinigrol的高效不对称全合成。
    权泽卫课题组在《先进材料》发表重要研究进展 近日,南科大化学系教授权泽卫课题组在新型纳米金属间化合物领域取得最新进展,该成果发表在材料领域顶级期刊《先进材料》(Advanced Materials,IF:25.806)。
    化学系徐晶课题组在《美国化学会志》发表成重要进展 近日,徐晶课题组再次在复杂笼状天然产物全合成领域取得重要进展菜鸟彩票最新网址,在《美国化学会志》发表重要研究论文,报道复杂笼状虎皮楠生物碱Caldaphnidine O的国际首次全合成。
    化学系徐晶课题组在《美国化学会志》发表成果 近日,我?;蹈苯淌谛炀Э翁庾槌晒Φ赝瓿闪烁丛踊⑵ら锛頓apholdhamine B及其内酯衍生物的对映选择性全合成工作,相关研究成果在《美国化学会志》(J. Am. Chem. Soc.)上发表。
    化学系刘心元课题组在自由基不对称化学领域取得重要研究进展 近日,我?;到淌诹跣脑翁庾樵诓欢猿铺绩C碳键偶联领域取得了重要研究进展。研究成果近期在《自然化学》(Nature Chemistry,IF:23.193)在线发表。
    化学系黄文忠课题组在《美国化学会志》发表最新研究成果 近日,我胁四癫势弊钚峦?;蹈苯淌诨莆闹铱翁庾槌晒铣闪艘幌盗懈叻⒐馇慷鹊念?III)配合物,并首次将其应用于有机电致发光二极管菜鸟彩票最新网址,取得重要研究进展菜鸟彩票最新网址。该成果在国际顶尖化学期刊《美国化学会志》

    刘心元

    教授

    化学系

    0755-88018314

    liuxy3@sustech.edu.cn

    研究方向
    自由基参与的不对称化学和有机氟化学


    刘心元博士,南方科技大学教授,国自然优秀青年基金获得者,入选教育部特聘教授(青年)。2001年在安徽师范大学化学系获学士学位,2004年在安徽师范大学与中科院上海有机研究所联合培养获硕士学位菜鸟彩票最新网址,师从王绍武教授和朱仕正研究员;2010年在香港大学获哲学博士学位菜鸟彩票最新网址,师从支志明院士菜鸟彩票最新网址。2010年4月至2012年9月先后在香港大学和美国The Scripps Research Institute从事博士后研究菜鸟彩票最新网址。2012年9月任南方科技大学化学系副教授,2018年晋升为终身教授菜鸟彩票最新网址。目前为止,以通讯作者身份在自由基不对称化学等领域发表高水平研究论文近60篇。其中包括影响因子大于10的论文如Nature Chemistry、Acc. Chem. Res.、Chem、J. Am. Chem. Soc.、Angew. Chem.菜鸟彩票最新网址、Nat. Commun.近30篇。


    2017年获得国家优秀青年科学基金和教育部青年特聘教授(青年),并荣获2017年日本化学会杰出讲席奖和2019年中美华人教授会杰出教授奖等多个奖项菜鸟彩票最新网址,主持十余项科研项目。包括国家自然科学基金优青项目1项,重点项目1项(CO-PI),面上项目1项,青年基金1项等。目前担任J. Fluorine Chem.编委。



    2019,亚洲尖端有机化学会讲席奖(ACP Lecture Award)

    2019,南方科技大学校长青年科研奖

    2019,中美华人教授联合会杰出教授奖

    2018,教育部特聘教授(青年)

    2017,国家自然科学基金优秀青年基金

    2016,南方科技大学优秀科研奖

    2013菜鸟彩票最新网址,深圳市孔雀计划B类人才

    2010,香港大学杰出研究生奖


    自由基参与的不对称化学和有机氟化学


     1. 国家自然科学基金委优秀青年项目、130万、项目负责人菜鸟彩票最新网址;2016.1 - 2019.12

    2. 国家自然科学基金委重点项目、302万、项目共同负责人;2019.1 - 2023.12

    3. 国家自然科学基金委面上项目菜鸟彩票最新网址,78 万、项目负责人;2016.1‐2019.12

    4. 国家自然科学基金委青年基金,25 万、项目负责人;2014.1‐2016.12

    5. 973 项目,2013CB834800、25 万菜鸟彩票最新网址、主要参与人; 2015.1‐2017.8



    1.      Xiao-Yang Dong+, Yu-Feng Zhang+, Can-Liang Ma+, Qiang-Shuai Gu+, Fu-Li Wang+, Zhong-Liang Li, Sheng-Peng Jiang and Xin-Yuan Liu * "A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling" Nature Chemistry 2019, DOI: 10.1038/s41557-019-0346-2.

    2.      Qiang-Shuai Gu, Zhong-Liang Li, and Xin-Yuan Liu* "Copper(I)-Catalyzed Asymmetric Reactions Involving Radicals" Acc. Chem. Res. 2019, DOI:10.1021/acs.accounts.9b00381.

    3.      Jin-Shun Lin, Tao-Tao Li, Ji-Ren Liu, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Yu-Long Guo, Xin Hong*, and Xin-Yuan Liu*, "Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes." J. Am. Chem. Soc. 2019, 141, 1074.

    4.      Jin-Shun Lin, Tao-Tao Li, Guan-Yuan Jiao, Qiang-Shuai Gu, Jiang-Tao Cheng, Ling Lv, and Xin-Yuan Liu*, "Chiral Br?nsted Acid‐Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes." Angew. Chem. Int. Ed. 2019, 58, 7092.

    5.      Yang Zeng, Xiao-Dong Liu, Xian-Qi Guo, Qiang-Shuai Gu*, Zhong-Liang Li*, Xiao-Yong Chang & Xin-Yuan Liu*, "Cu/Chiral Phosphoric Acid-Catalyzed Radical-Initiated Asymmetric Aminosilylation of Alkene with Hydrosilane." Science China Chem. 2019, 10.1007/s11426-019-9528-2.

    6.      Gui?Chun Fang, Yong?Feng Cheng, Zhang?Long Yu, Zhong?Liang Li, Xin?Yuan Liu菜鸟彩票最新网址,"Recent Advances in First?Row Transition Metal/Chiral Phosphoric Acid Combined Catalysis." Top. Curr. Chem. 2019, 377, 23.

    7.      Na Wang, Qiang-Shuai Gu, Zhong-Liang Li, Zhuang Li, Yu-Long Guo, Zhen Guo, and Xin-Yuan Liu*, "Direct Photocatalytic Synthesis of Medium-Sized Lactams through C–C Bond Cleavage." Angew. Chem. Int. Ed201857, 14225.

    8.      Xi-Tao Li, Qiang-Shuai Gu, Xiao-Yang Dong, Xiang Meng, and Xin-Yuan Liu*, "Cinchona Alkaloid‐Based Sulfonamide/Copper Catalyst for Asymmetric Radical Oxytrifluoromethylation of Alkenyl Oximes." Angew. Chem. Int. Ed. 201857, 7668.

    9.      Liu Ye, Qiang-Shuai Gu, Guo-Cong Chen, and Xin-Yuan Liu,* "Construction of Bicyclo[3.1.0]hexanes Containing Vicinal All-Carbon Quaternary Stereocenters via Radical Asymmetric Intramolecular α-Cyclopropanation of Aldehydes." Nat. Commun. 2018, 9, 227.

    10.  Jin-Hao Zhao, Yong Yang, Jin-Xin Che, Jun Zuo, Xiao-Hua Li, Yong-Zhou Hu, Xiao-Wu Dong,* Liang Gao,* and Xin-Yuan Liu*, “Compartmentalization of Incompatible Polymers within Metal–Organic Frameworks towards Homogenization of Heterogeneous Hybrid Catalysts for Tandem Reactions.” Chem. Eur. J201824, 9903. 

    11.  Na Wang, Jian Wang, Yu-Long Guo, Lei Li, Yan Sun, Zhuang Li, Hong-Xia Zhang, Zhen Guo,  Zhong-Liang Li* and Xin-Yuan Liu *, “Oximinotrifluoromethylation of unactivated alkenes under ambient conditions.” Chem. Commun. 201854, 8885.

    12.  Na Wang, Liu Ye, Zhong-Liang Li, Lei Li, Zhuang Li, Hong-Xia Zhang, Zhen Guo, QiangShuai Gu* and Xin-Yuan Liu*, “Hydrofunctionalization of Alkenols Triggered by Addition of Diverse Radicals to Unactivated Alkenes and Subsequent Remote Hydrogen Atom Translocation.” Org. Chem. Front. 20185, 2810.

    13.  Xiao-Wu Dong*, Yong Yang, Jin-Xin Che, Jun Zuo, Xiao-Hua Li, Liang Gao, Yong-Zhou Hu and Xin-Yuan Liu*, “Heterogenization of homogeneous chiral polymers in metal–organic frameworks with enhanced catalytic performance for asymmetric catalysis.” Green Chem. 201820, 4085.

    14.  Xi-Tao Li, Ling Lv, Qiang-Shuai Gu,*, and Xin-Yuan Liu*, “Copper-catalyzed radical oxytrifluoromethylation of alkenyl oximes at ambient temperature.” Tetrahedron, 201874, 6041.

    15.  Yu Tian, Su Chen, Qiang-Shuai Gu, Jin-Shun Lin, Xin-Yuan Liu*, “Amino- and azidotrifluoromehtylation of alkenes.” Tetrahedron Lett. 2018, 59, 203. (Invited Digest)

    16.  Na Wang, Qiang-Shuai Gu*, Yong-Feng Cheng, Lei Li, Zhong-Liang Li, Zhen Guo*, and Xin-Yuan Liu*, “Visible-Light Promoted Preparation of Trifluoromethylated Tetrahydrofuran and Tetrahydropyran.” Chin. J. Org. Chem. 2019, 39, 200.

    17.  Xue-Fei Li, Jin-Shun Lin, Jian Wang, Zhong-Liang Li, Qiang-Shuai Gu, and Xin-Yuan Liu*, “Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Radical- Initiated Aminoarylation of Alkenes.” Acta Chim. Sinica 201876, 878.

    18.  Fu-Li Wang, Xiao-Yang Dong, Jin-Shun Lin, Yang Zeng, Guan-Yuan Jiao, Qiang-Shuai Gu, Xian-Qi Guo, and Xin-Yuan Liu*, “Catalytic Asymmetric Diamination of Unactivated Alkene with Dialkylaminyl Radical” Chem 2017, 3, 979.

    19.  Lei Li, Zhong-Liang Li, Qiang-Shuai Gu, Na Wang, Xin-Yuan Liu,* "A Remote Radical Vinyl Migration Strategy to Access Medium- and Large-sized Cyclic Alkenes" Sci. Adv. 2017, 3, e1701487.

    20.  Lei Li, Liu Ye, Shao-Fei Ni, Zhong-Liang Li, Su Chen, Yi-Meng Du, Xiao-Hua Li, Li Dang* and Xin-Yuan Liu,* "Phosphine-catalyzed remote α-C–H bond activation of alcohols or amines triggered by the radical trifluoromethylation of alkenes: reaction development and mechanistic insights" Org. Chem. Front. 2017, 4, 2139.

    21.  Xue-Fei Li, Jin-Shun Lin and Xin-Yuan Liu,* “Catalytic Radical Intramolecular Aminoperfluoroalkylation and Aminodifluoromethylation of Unactivated Alkenes with Fluoroalkylsulfonyl Chlorides” Synthesis 2017, 49, 4213.

    Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

    22.  Jin-Shun Lin, Fu-Li Wang, Xiao-Yang Dong, Wei-Wei He, Yue Yuan, Su Chen, and Xin-Yuan Liu,* "Catalytic Asymmetric Radical Aminoperfluoroalkylation and Aminodifluoromethylation of Alkenes: A Versatile Platform for Enantioenriched-Fluoroalkyl Amines" Nat. Commun. 2017, 8, 14841.

    23.  Yong-Feng Cheng, Xiao-Yang Dong, Qiang-Shuai Gu, Zhang-Long Yu, and Xin-Yuan Liu* “Achiral Pyridine Ligand-Enabled Enantioselective Radical Oxytrifluoromethylation of Alkenes with Alcohols” Angew. Chem., Int. Ed. 2017, 56, 8883.

    Selected as Cover pictures.

    Highlighted by Synfacts 2017, 13(10), 1042.

    24.  Taotao Li, Peng Yu, Yi-Meng Du, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* "Dual-Catalyzed Enantioselective Remote C?H Functionalization Triggered by Radical Trifluoromethylation of Alkenes: Highly Selective Formation of C?CF3 and C?C Bonds" J. Fluorine Chem. 2017, 203, 210. (invited paper for a special issue).

    25.  Lei Li, Qiang-Shuai Gu, Na Wang, Ping Song, Zhong-Liang Li, Xiao-Hua Li, Fu-Li Wang, and Xin-Yuan Liu,* "1,2-Difunctionalization-Type (Hetero)arylation of Unactivated Alkenes Triggered by Radical Addition/Remote (Hetero)aryl Migration" Chem. Commun. 2017, 53, 4038.

    26.  Ping Song, Peng Yu, Jin-Shun Lin, Yiqun Li,* Ning-Yuan Yang, and Xin-Yuan Liu,* "Transition-Metal-Free β?C?H Bond Carbonylation of Enamides or Amides with a Trifluoromethyl Group as CO Surrogate for the Synthesis of 1,3-Oxazin-6-ones" Org. Lett. 2017, 19, 1330.

    27.    Lei Li, Zhong-Liang Li, Fu-Li Wang, Zhen Guo, Yong-Feng Cheng, Na Wang, Chao Fang, Jingjiang Liu, Chunhui Hou, Bin Tan, and Xin-Yuan Liu,* "Radical Aryl Migration Enables Diversity-Oriented Synthesis of Structurally Diverse Medium/Macro- or Bridged-Rings" Nat. Commun. 2016, 7, 13852.

    28.    Zhong-Liang Li, Xiao-Hua Li, Na Wang, Ning-Yuan Yang, and Xin-Yuan Liu,* "Radical-Mediated 1,2-Formyl/carbonyl-Functionalization of Alkenes and Application to Construction of Medium-Sized-, Fused-, and Bridged-Ring Systems" Angew. Chem., Int. Ed. 2016, 55, 15100.

    29.    Jin-Shun Lin, Xiao-Yang Dong, Tao-Tao Li, Na-Chuan Jiang, Bin Tan, and Xin-Yuan Liu,* "A Dual-Catalytic Strategy to Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes" J. Am. Chem. Soc. 2016, 138, 9357.

    Highlighted by “Synfacts 2016, 1020”. Highlighted by “Chin. J. Org. Chem. 2016, 36, 2247”.

    30.    Lin Huang, Liu Ye, Xiao-Hua Li, Zhong-Liang Li, Jin-Shun Lin, and Xin-Yuan Liu,* "Stereoselective Radical Cyclization Cascades Triggered by Addition of Diverse Radicals to Alkynes to Construct 6(5)‐6‐5 Fused Rings" Org. Lett., 2016, 18, 5284.

    31.    Na Wang, Lei Li, Zhong-Liang Li, Ning-Yuan Yang, Zhen Guo,* Hong-Xia Zhang, and Xin-Yuan Liu,* "Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies" Org. Lett., 2016, 18, 6026.

    32.    Ning-Yuan Yang, Zhong-Liang Li, Liu Ye, Bin Tan, and Xin-Yuan Liu,* "Organic base-catalysed solvent-tuned chemoselective carbotrifluoromethylation and oxytrifluoromethylation of unactivated alkenes" Chem. Commun., 2016, 52, 9052.

    From themed collection 2016 Emerging Investigators by Chem. Commun.

    33.    Xiao-Long Yu, Liping Kuang, Su Chen, Xiao-Long Zhu, Zhong-Liang Li, Bin Tan, and Xin-Yuan Liu,* "Counteranion-Controlled Unprecedented Diastereo- and Enantioselective Tandem Povarov Reaction for Construction of Bioactive Octahydro-dipyrroloquinolines" ACS Catal. 2016, 6, 6182.

    34.    Na Wang, Sheng-Cai Zheng, Lin-Lin Zhang, Zhen Guo,* and Xin-Yuan Liu* "Nickel(0)-Catalyzed Denitrogenative Transannulation of Triazoles with Alkynes: Mechanistic Insights of Chemical Reactivity, Regio- and Enantioselectivity from Density Functional Theory and Experiment" ACS Catal. 2016, 6, 3496.

    35.    Taotao Li, Peng Yu, Jin-Shun Lin, Yonggang Zhi,* and Xin-Yuan Liu,* "Copper-Catalyzed Redox-Triggered Remote C–H Functionalization: Highly Selective Formation of C–CF3 and C–O Bonds" Chin. J. Chem. 2016, 34, 490.

    Invited paper for the Special Issue of “Trifluoromethylation and Trifluoromethythiolation Reactions”

    36.    Can-Liang Ma, Xiao-Hua Li, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong,* Bin Tan,* and Xin-Yuan Liu,* "Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I)" Org. Chem. Front. 2016, 3, 324.

    From themed collection 2015 Emerging Investigators by OCF.

    37.    Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* and Xin-Yuan Liu,* "Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation" Angew. Chem., Int. Ed. 2015, 54, 9528.

    Highlighted by “Synfacts 2015, 11, 1029”.

    38.    Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* and Xin-Yuan Liu,* "Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter" Angew. Chem., Int. Ed. 2015, 54, 7847.

    Highlighted by “Chin. J. Org. Chem. 2015, 35, 1802”.

    39.    Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* and Xin-Yuan Liu,* "Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles" Angew. Chem., Int. Ed. 2015, 54, 4041.

    Selected for a Cover Picture.

    40.    Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu,* "Enantioselective C–H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene" Angew. Chem., Int. Ed. 2014, 53, 11890.

    Highlighted by “Synfacts 2014, 10, 1281”. Highlighted by “Angew. Chem., Int. Ed. 2017, 56, 49”.

    41.    Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu,* and Bin Tan,* "Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction" Nat. Commun. 2016, 7, 10677.

    42.    Jian Zhang, Shao-Xia Lin, Dao-Juan Cheng, Xin-Yuan Liu,* and Bin Tan,* "Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction" J. Am. Chem. Soc. 2015, 137, 14039.

    Highlighted by “Synfacts 2016, 12, 86”.

    43.    Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu,* Bin Tan,* "Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2?Naphthols" J. Am. Chem. Soc. 2015

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